Corn Cob Xylan-based Nanoparticles: Ester Prodrug of 5-Aminosalicylic Acid for Possible Targeted Delivery of Drug

نویسندگان

  • Samit Kumar
  • Yuvraj Singh Negi
چکیده

Xylan, a green biopolymer extracted from agro-waste corn cob may be used as a tool to deliver drugs principally to the colon because of their timely retention in the physiological environment of stomach and small intestine and can only be degraded in colon by vast anaerobic microflora such as Bifidobacterium. Present research work relates to incorporate the drug molecule such as 5-aminosalicylic acid (5-ASA) into polymeric backbone of xylan by intermolecular covalent bond formation so that absorption of the drug is prevented in upper gastrointestinal tract (GIT) and minimizing the systemic side effects. The intermolecular covalent formation of 5-ASA to polymeric backbone of xylan was evaluated by means FT-IR, H-NMR, solid C-NMR spectroscopy. It may further be confirmed by TGA/DTA and powder X-ray diffraction. The resulting prodrug was self assembled into spherical nanoparticles with an average diameter of 54±11nm and 13±4nm as evaluated by means of AFM and TEM technique respectively. The prodrugs were synthesized which might be active against inflammatory bowel diseases, a novel idea towards advanced drug delivery by corn cob xylan will be discussed.

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تاریخ انتشار 2012